Pandemics, like COVID-19, intensify inequalities for women and girls, particularly for those already in a vulnerable situation such as older persons; migrants, displaced person and refugees; persons with disabilities; LGBTI persons; survivors of gender-based violence; persons belong to national minorities and people in detention and institutions. In such crises, it is important to understand and mitigate factors that can exacerbate inequalities, and to identity women and girls who face the greatest risk of being left behind in the access to detection and treatment.