This document offers evidence-based guidelines on the planning, implementation, management and evaluation of youth peer education (YPE) programmes, and it provides suggestions on how to apply the guidelines. The guidelines refer to current research on peer education and provide real-world examples from YPE programmes globally. When applied to a new or existing YPE programme, the guidelines have the potential to improve the quality of the programme and to signify to donors and others that the program is formed around evidence-based practices. The guidelines are relevant to policymakers, programme managers, supervisors, trainers and peer educators themselves.